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The present study examined the hypothesis that HMDA, AMPA/Kainate, and metabotropic (mGlu) glutamate receptors contribute to a behavioral stimulation induced by activation of dopamine receptors by comparing responses in apomorphine-induced cage climbing behaviors In mice. MK-801, CNQX, and MCPG were served as the NMDA receptors AMPA/Kainate receptor, and mGlu receptor antagonist, respetive1y, to elucidate the g1utamatergic modulation in apomorphine-induced dopaminergic activation in mice. Drugs were administered intracerebroventricularly (I.c.v.) into the mouse brain 15 min before the apomorphine treatment (2 mg/kg, s.c.). L.c.v. Injection of MK-801 inhibited the apomorphine-induced carte climbing behavior dose-dependently. Howeverf treatments with CNQX and MCPC did not any significant change in apomorphine-induced cage climbing behavior in mice. These results suggest that stimulation of NMDA type of glutamate receptors could contribute to the dopaminergic stimulation, but not AMPA/Kainate and mGlu type glutamate receptors.
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